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Child-Pugh Classification of Severity of Liver Disease

Modified Child-Pugh classification of severity of liver disease according to the degree of ascites, the plasma concentrations of bilirrubin and albumin, the prothrombin time, and the degree of encephalopathy.

Parameter

Points assigned

1

2

3

Ascites

Absent

Slight

Moderate

Bilirrubin, mg/dL

</= 2

2-3

>3

Albumin, g/dL

>3.5

2.8-3.5

<2.8

Prothrombin time

* Seconds over control

* INR

 

1-3

<1.8

 

4-6

1.8-2.3

 

>6

>2.3

Encephalopathy

None

Grade 1-2

Grade 3-4

 

A total score of 5-6 is considered grade A (well-compensated disease); 7-9 is grade B (significant functional compromise); and 10-15 is grade C (descompensated disease). These grades correlate with one- and two-year patient survival.

Grade

Points

One-year patient survival (%)

Two-year patient survival (%)

A: well-compensated disease

5-6

100

85

B: significant functional compromise

7-9

80

60

C: descompensated disease

10-15

45

35

 

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